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Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Season 22 Episode
- Season 21 Lena Dunham; Max Greenfield; Brandy Clark
- Season 21 Joel McHale; Marv Albert; Washed Out
- Season 21 Scarlett Johansson; John Grant
- Season 21 Anderson Cooper; Bobby Moynihan; Will Hoge
- Season 21 Mindy Kaling; Jeff Altman; Red Fang
- Season 21 Bill Cosby; Sleigh Bells
- Season 21 Michael Strahan; Jennifer Nettles
- Season 21 Kevin Hart; Mo Rocca; The Orwells
- Season 21 Brian Williams; Rosanne Cash
- Season 21 Don Cheadle; Myq Kaplan; Roadkill Ghost Choir
- Season 21 Andy Samberg; Michael B. Jordan; Ellie Goulding
- Season 21 Martin Scorsese; Allison Williams; Cults
- Season 21 Rachel Maddow; Spike Jonze; No Age
- Season 21 Kevin Bacon; Pat McGann; Devon Avenue
- Season 21 Louis C.K.; B.J. Ganem; Artic Monkeys
- Season 21 Eric Stonestreet; Nick Goepper; Bastille
- Season 21 Drew Brees; B.J. Novak; Against Me!
- Season 21 Dr. Phil McGraw; Danny Koker; Dum Dum Girls
- Season 21 Bill Murray; Eagulls
- Season 21 Will Arnett; Broken Bells
- Season 21 George Clooney; Sting
- Season 21 Matt Damon; Lenny Kravitz
- Season 21 Patrick Stewart; The Flaming Lips
- Season 21 Regis Philbin; Ms. Lauryn Hill
- Season 21 Kevin Spacey, Amber Heard, a Top Ten List presented by the cast of
- Season 21 Sage Kotsenburg, Kate Mara
- Season 21 Kaitlyn Farrington, Lupita Nyong'o, Little Dragon
- Season 21 Keri Russell, Terry Fator
- Season 21 Pauley Perrette, Jeff Caldwell, Lake Street Dive
- Season 21 Kaley Cuoco-Sweeting, Dale Earnhardt, Jr., The Fray
- Season 21 Olympic Gold Medalist Ted Ligety, Kat Dennings, Lo-Fang
- Season 21 Meredith Vieira, Band of Horses
- Season 21 Stupid Human Tricks, Simon Helberg, Young the Giant
- Season 21 Jack (Jungle) Hanna, Jake Johannsen
- Season 21 Zach Braff, Sgt. Brendan Marrocco & Dr. Andrew Lee, Future Islands
- Season 21 Michael Keaton, Phantogram
- Season 21 Tom Selleck, Carrie Brownstein, David Nail
- Season 21 Tom Brokaw, Andrew Hadlock, Bob Mould
- Season 21 Mary-Louise Parker, Lenny Marcus, Joan Jett & the Blackhearts
- Season 21 Sen. John McCain, Little Mix
- Season 21 Jason Bateman, Miles Teller, Gary Allan
- Season 21 Sylvester Stallone, Theo James, Ledisi
- Season 21 Bryan Cranston, Melissa Rauch, Le1f
- Season 21 Bill O'Reilly, Nick Griffin, the Dough Rollers
- Season 21 Jimmy Carter
- Season 21 Emma Watson, Nick Offerman, a musical tribute to Johnny Cash
- Season 21 Peter Dinklage, Hari Kondabolu, Sage the Gemini
- Season 21 Cobie Smulders, Nick Cannon, Manchester Orchestra
- Season 21 Kristin Chenoweth, Amy Schumer, Johnnyswim
- Season 21 Bill Murray, Martha Stewart, Lady Gaga
- Season 21 Johnny Depp, Kevin Drew
- Season 21 Billy Crystal, Tony Hale, Liv Warfield
- Season 21 Rob Lowe, Brooklyn Decker, London Grammar
- Season 21 Lindsay Lohan, Jamie Edwards, Real Estate
- Season 21 Courteney Cox, Jimmie 'J.J.' Walker, Christina Perri
- Season 21 Stephen Colbert, Robin Roberts, Kelis
- Season 21 Sally Field, Timothy Simons, Needtobreathe
- Season 21 Neil Patrick Harris, Sarah Hyland, Ray LaMontagne
- Season 21 Piedmont Bird Callers, Michael J. Fox, Naughty Boy
- Season 21 Joel McHale, Vera Farmiga, Aloe Blacc
- Season 21 Lucy Liu, Ziggy Marley
- Season 21 Kiefer Sutherland, Adam Resnick, Benjamin Booker
- Season 21 Louis C.K., a performance from the Broadway cast of Rocky
- Season 21 Don Rickles, Carmen Lynch, the Ghost of a Saber Tooth Tiger
- Season 21 Shailene Woodley, Peyton Manning
- Season 21 Jon Cryer, Elizabeth Olsen, Foster the People
- Season 21 Mariah Carey, Rick Harrison
- Season 21 James Franco, Idina Menzel, a performance by the Broadway cast of 'If/Then'
- Season 21 Nathan Fillion, Tom Dreesen, Hunter Hayes
- Season 21 Harry Connick Jr., Jesse Eisenberg, the Black Keys
- Season 21 Jim Parsons, Julie Chen, Hozier
- Season 21 Barbara Walters, Elle Fanning, Randy Houser
- Season 21 Adam Sandler, Thomas Haden Church
- Season 21 Lea Michele, Andy Kindler, Chromeo
- Season 21 Jack Hanna, Stephen Malkmus & the Jicks
- Season 21 Kid scientists, Sarah Silverman, We Are Scientists
- Season 21 Sgt. Kyle J. White, Judy Greer, Dierks Bentley
- Season 21 Donald Trump, Indianapolis 500 winner Ryan Hunter-Reay, Elizabeth Cook
- Season 21 Martin Short, John Oliver, Spanish Gold
- Season 21 Anderson Cooper, Victor Espinoza, the Afghan Whigs
- Season 21 Hugh Jackman, Joe List, Elvis Costello
- Season 21 Kelsey Grammer, Willie Nelson
- Season 21 Dave Chappelle, Laura Prepon, a Top Ten List presented by Miss USA, the Orwells
- Season 21 Christopher Walken, Janelle Monae, Tatiana Maslany, Miss USA 2014
- Season 21 Regis Philbin, Paul Morrissey, First Aid Kit
- Season 21 Susan Sarandon, Whitney Cummings, Angel Olsen, David Sanborn
- Season 21 Olivia Wilde, Shep Gordon, Empires
- Season 21 Dana Carvey, Ellie Kemper, Sam Smith
- Season 21 Paul Rudd, Jeff Altman, John Doe
- Season 21 Adam Levine, Gen. Frank J. Grass, Broken Bells
- Season 21 Melissa McCarthy, Rachelle Lefevre, Phish
- Season 21 Mark Wahlberg, Ben Falcone, Hurray for the Riff Raff
- Season 21 Mark Ruffalo, Former Marine Lance Cpl. William 'Kyle' Carpenter
- Season 21 Halle Berry, Steve Young, War on Drugs
- Season 21 Joan Rivers, Capital Cities
- Season 21 Lizzy Caplan, Sleeper Agent
- Season 21 Michael Douglas, Paul Morrissey, Kiesza
- Season 21 Kurt Russell, Hannibal Buress, Sturgill Simpson
- Season 21 Jason Segel, Liv Tyler, Trampled By Turtles
- Season 21 Emma Stone, Nathan Fielder, American Authors
- Season 21 Colin Firth, Tommy Johnagin, EMA
- Season 21 Jeff Daniels, Norah O'Donnell, A Special Performance of 'MacArthur Park'
- Season 21 Ricky Gervais, Taylor Schilling, Eli Young Band
- Season 21 Eric Stonestreet, Brody Dalle
- Season 21 Staff Sgt. Ryan Pitts, Sharon Van Etten
- Season 21 John C. Reilly, Rachelle Lefevre, Conor Oberst
- Season 21 Chris Pratt, Rodrigo y Gabriela
- Season 21 Zoe Saldana, Crash
- Season 21 Julia Louis-Dreyfus, Simon Amstell, David Gray
- Season 21 Bruce Willis, the Gaslight Anthem
- Season 21 Joseph Gordon-Levitt, Novak Djokovic, Robby Johnson
- Season 21 Kathy Griffin, Ken Burns, Jeremy Messersmith
- Season 21 Serena Williams, Chadwick Boseman, Echo & the Bunnymen
- Season 21 Michael Cera, dock diving dogs, Lyle Lovett
- Season 21 Howie Mandel, EMA
- Season 21 James McAvoy, Chris Russo, The Last Internationale
- Season 21 Mike Myers, Bonnie McFarlane, John Fullbright
- Season 21 Luke Wilson, Julie Chen, Lee Brice
Late Show with David Letterman - Season 21 Episode 105 Staff Sgt. Ryan Pitts, Sharon Van Etten
6.30 63 minutes 
