When an infant suffers breathing trouble and liver failure, House and the team must look at the medical history of the mother in order to find an answer, and ultimately land on a discovery that forces the mother to jeopardize not only her child's health but her own. Meanwhile Taub and Foreman must find a new female doctor to fill the spot vacated by Thirteen and House and Wilson learn a thing or two about parenting while caring for Cuddy's daughter.